Computational methods for reproductive and developmental by Donald R. Mattison PDF

By Donald R. Mattison

ISBN-10: 1439861080

ISBN-13: 9781439861080

Building from the viewpoint of reproductive and developmental biology, Computational equipment for Reproductive and Developmental Toxicology provides a well timed and complete review of methods in reproductive and developmental toxicology.

The ebook, that's a part of the QSAR in Environmental and well-being Sciences sequence, is split into 3 wide sections. the 1st offers a evaluation of tools and methods to fulfill the necessity for defense exams in product improvement and regulatory methods for environmental chemical substances. the subsequent one reports the organic techniques and endpoints inquisitive about copy and improvement.

The ultimate and biggest part summarizes protocols for comparing organic tactics and endpoints inside of replica and improvement. It additionally discusses informatics assets and computational tools.

The booklet takes a cross-disciplinary method bringing jointly developmental, reproductive and platforms biology, chemistry, toxicology, pharmacology, biostatistics, info sciences, bioinformatics, and computational ways. This helpful source presents these within the box with the required wisdom to judge either vintage and up to date techniques to signify toxicity.

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Extra info for Computational methods for reproductive and developmental toxicology

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Hass, Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat, Int. J. Androl. 31 (2008), pp. 241–248. 40. gov/ExposureReport/. 41. htm. 42. S. R. J. B. T. M. M. M. Rotroff, I. M. J. Dix, In vitro screening of environmental chemicals for targeted testing prioritization: The ToxCast project, Environ. Health Perspect. 118 (2010), pp. 485–491. 2 Ovarian Cycle..................................................................................................

22. P. Flint, A micromass culture method for rat embryonic neural cells, J. Cell. Sci. 61 (1983), pp. 247–262. 23. A. Brown, H. Spielmann, R. P. J. J. Jeläinek, E. Koch, H. R. K. Y. F. Repetto, R. Vogel, and R. Wiger, Screening chemicals for reproductive toxicity: The current alternatives; The report and recommendations of an ECVAM/ETS workshop (ECVAM workshop 12), Altern. Lab. Anim. 23 (1995), pp. 868–882. 24. E. Genschow, H. Spielmann, G. Scholz, A. Seiler, N. Brown, A. Piersma, M. Brady, N. Clemann, H.

For this purpose, three main goals are considered, that is, (1) improve knowledge about properties and uses of individual chemical substances to ensure a high level of protection of human health and the environment, (2) increase the speed and efficiency of the risk assessment process, and (3) explore the free movement of chemical substances, on their own, in preparations and in products while enhancing competitiveness and innovation [2]. 25 REACH and Environmental Chemicals Under the term chemicals, REACH includes any organic or inorganic compounds, substances, and additives in the natural state or obtained by any manufacturing process.

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Computational methods for reproductive and developmental toxicology by Donald R. Mattison

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