By Stephen K. Tyring
ISBN-10: 0203996976
ISBN-13: 9780203996973
ISBN-10: 0824754085
ISBN-13: 9780824754082
In contrast to the other resource at the topic, Antiviral brokers, Vaccines, and Immunotherapies analyzes the advantages and barriers of each to be had drug, vaccine, and immunotherapy used in the prevention and keep an eye on of viral ailments. This reference presents in-depth experiences of greater than 50 medicinal drugs and antiviral brokers for HIV, human herpesviruses, human papillomaviruses (HPV), influenza, breathing syncytial virus, hepatitis B, and analyzes their mechanisms of motion, dosage, unwanted effects, and drug resistance. The ebook additionally offers an summary of using immunoglobulins and monoclonal antibodies for antiviral use and provides vast references, tables, and figures in the course of the textual content.
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Extra info for Antiviral Agents, Vaccines and Immunotherapies
Sample text
Mason, C. Lane, A. Tryggvesson, E. Rybicki, A. D. C. Rose. 2003. Oral immunogenicity of human papillomavirus-like particles expressed in potato. J Virol 77: 8702–8711. 6. L. C. H. M. Colford, Jr. 2003. Bias due to secondary transmission in estimation of attributable risk from intervention trials. Epidemiology 14: 442–450. 7. , L. Corey, R. Cone, A. Hobson, G. Davis, and J. Zeh. 1997. Frequent genital herpes simplex virus 2 shedding in Introduction 23 immunocompetent women: effect of acyclovir treatment.
However, it should be noted that resistance to zidovudine and lamivudine gives cross-resistance to abacavir (105). In patients with lipoatrophy caused by stavudine or zidovudine sensitivity, abacavir results in modest increases in limb fat over 24 weeks (73). In patients who have previously been heavily treated with other nucleoside analogues, the addition of abacavir would be ineffective. Abacavir combined with zidovudine and lamivudine is now marketed as Trizivir for HAART therapy. Adverse Events Hypersensitivity reactions.
It is a synthetic carboxycyclic nucleoside with a 6-cyclopropylamino modification. The structure, brand names, and approved usage are shown in Fig. 8. Abacavir is the most powerful nucleoside analogue and one of the most powerful antiretroviral drugs currently available. Its use results in reduction in viral loads and increases in CD4 counts which are unparalleled by any other nucleoside analogue and are similar to most potent PIs (100). Abacavir is normally administered as 300-mg doses twice daily although there is some indication that a 600-mg dose once daily is equally effective (101).
Antiviral Agents, Vaccines and Immunotherapies by Stephen K. Tyring
by Anthony
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